Hemolíticas. Keywords: Autoimmune hemolytic anemia, cold agglutinin disease, autoantibodies, treatment. Palabras clave: Anemia hemolitica autoinmune. Request PDF on ResearchGate | Protocolo diagnóstico de las anemias hemolíticas | The hemolytic anemias diagnosis remains a clinical challenge. Once a. Download Citation on ResearchGate | On Nov 1, , M. J. García Rodríguez and others published Protocolo diagnóstico de las anemias hemolíticas.

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This case report describes the clinical course, laboratory alterations, molecular diagnosis, and management of the first PK-deficient Brazilian WHWT dog, suggesting the potential worldwide distribution of this disorder and that it possibly goes by under-diagnosed.


The leukopenia and thrombocytopenia in the WHWT described here is not typical of PK deficiency and may indicate a secondary illness affecting the bone marrow. Pulmonary hypertension in sickle cell disease. Treatment of AIHA, especially in cold antibody-mediated disease, represents a therapeutical challenge.

Causes of death in sickle-cell disease in Jamaica. Roberto Ferreira Pinto Machado. Services on Demand Journal.


Two homozygous UROS missense mutations cause the enzyme deficiency and porphyrin accumulation. Affected dogs may be first discovered only because of very anekias mucous membranes on routine examination. Recently, rituximab has been shown to be an hemollticas treatment option in children as well as in adults for relapsed and refractory autoimmune haemolytic anaemias and in patients who are medically unsuited for espenectomy.


Pulmonary hypertension in patients with sickle cell disease: As there was also a decline in platelet and leukocyte counts, a hematopoietic failure for other reasons than PK-deficiency may have been present.

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Intravenous injection of sonicated blood induces pulmonary microthromboembolism in rabbits with ligation of the xnemias artery. In previous clinical visits babesiosis was suspect due to severe anemia and also giardiasis because the puppy had some episodes of loose and greennish faeces.

Hum Mol Genet 19, Pulmonary hypertension in sickle hemolificas hemoglobinopathy: Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat.

Since this is the first case report of PK-deficiency from Brazil, it will be important to investigate the presence of asymptomatic carriers to avoid the spreading of this disorder Giger Changes in coagulation and fibrinolysis in patients with sickle cell disease compared with healthy black controls.

In this case report, we conclude that the prognosis would have been better if the etiology of severe anemia was identified soon. J Am Vet Med Assoc Hemolytic anemia caused by hereditary pyruvate kinase deficiency in a West Highland White Terrier dog. Clinical course of pyruvate kinase deficiency in Abyssinian and Somali cats. Blood transfusions from compatible donors are sometimes needed when the anemia becomes most severe and the PK-deficient animal shows major clinical signs.

Anemia Hemolítica Autoinmune

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. The anti-CD20 monoclonal antibody rituximab has gained widespread acceptance in the management of haematologic disorders with autoantibodies production.


Left ventricular filling pressure in sickle cell anemia. Usually the dogs that live longer develop severe liver disease with hemosiderosis. Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension. Pyruvate kinase PK deficiency in newborns: Breed-specific hereditary diseases and genetic screening.

Inherited metabolic disease in companion animals: Several hereditary erythrocytic disorders that cause hemolytic anemia and additional unique features have been described in dogs and cats, including membrane defects and enzyme deficiencies; however, interestingly enough no hemoglobinopathies have been discovered in companion animals. Clinicians often do not consider hereditary RBC defects, as they are believed to occur rarely.

Thrombo-embolic disease after splenectomy for hereditary stomatocytosis.

There was no evidence of blood loss anemia, and fecal examinations for intestinal parasites were negative. Identification of a 6 base pair insertion in West Highland White Terriers with erythrocyte pyruvate kinase deficiency.

In anemuas case, PK deficiency was suspected because of persistent exercise intolerance, episodes of syncope, and persistent anemia even after blood transfusions. Vet Clin Pathol 20, Blood proteins C and S in sickle cell disease.