Irsogladine maleate (JP17); Gaslon N (TN). Formula. C9H7Cl2N5. C4H4O4. Exact mass. Mol weight. Structure, Mol file KCF file DB search. View and buy high purity Irsogladine maleate from Tocris Bioscience. PDE4 inhibitor; antiulcer agent. Description. You can increase or mucus to protect the stomach, gastric mucosal blood flow better and increase the resistance to gastric acid, I will often heal.

Author: Vok Mojar
Country: Estonia
Language: English (Spanish)
Genre: Software
Published (Last): 5 May 2014
Pages: 421
PDF File Size: 16.43 Mb
ePub File Size: 18.8 Mb
ISBN: 140-8-28284-456-6
Downloads: 24353
Price: Free* [*Free Regsitration Required]
Uploader: Kagasar

Please sign in using your account on one of the following social maletae. Furthermore, Min mice treated with irsogladine maleate had a significantly reduced number of intestinal polyps.

The small intestine was divided into the proximal segment 4 cm in length and the proximal middle and distal halves of the remainder. Secosterol-A and -B were synthesized according to the procedure reported by Wentworth et al. Based on the reduced levels of reactive carbonyl species RCs in Min mice treated with irsogladine maleate, the mechanisms underlying the suppressive effect of the drug on intestinal tumorigenesis are also discussed. Have you used Irsogladine maleate?

Irsogladine maleate Supplier | CAS | MN | Tocris Bioscience

Currently there are no citations for Irsogladine maleate. Long-term effect of aspirin on colorectal cancer incidence and mortality: Activates gap-junctional intercellular communication improving gastric mucosal barrier function.

This ion product was assigned to the 5-dimethylaminonaphthalenesulfonyl moiety derived from the positively ionized DH derivatives. Annu Rev Cell Biol. Irsoogladine RCs abbreviations are listed in the Materials and Methods section.

Irsogladine maleate

We chose six gastric mucosal protectants ecabet sodium hydrate, irsoglaine maleate, rebamipide, sofalcone, teprenone and troxipide and examined their effects on the activity of oxidative stress-related transcriptional factors, including AP-1, NF-jB, NRF2, p53 and STAT3, in Caco-2 cells using a luciferase reporter gene assay.


Angel P, Karin M. Structure, regulation and function of NF-kappa B. All of the free RCs detected in the liver samples taken from 0 A. The total number of polyps decreased with the administration of 5 and 50 ppm irsogladine maleate to Moreover, the levels of oxidative stress-related markers, reactive carbonyl species, in the livers of Min mice were clearly decreased following the administration of irsogladine maleate.

Each sample was injected seven times to complete the monitoring of the SRM transitions. A collection of over products lrsogladine cardiovascular research, the guide includes research tools for the study of:. However, this potential has not been clarified, and screening methods that completely evaluate the activities of oxidative stress-related transcriptional malate have not been performed.

Moreover, the levels of oxidative stress-related markers, reactive carbonyl species, in the livers of Min mice were clearly decreased following the administration irsoglaadine irsogladine maleate.

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion.

Published online Jan The levels of serum triglyceride, free fatty acid, and total cholesterol were measured as previously reported [ 29 ].

Creating an account with us makes your shopping experience much easier and faster. For Irsogladins Use Only. Associated Data Supplementary Materials oncotargets This study demonstrated that irsogladine maleate suppresses intestinal polyp formation in Min mice partly through the NF-jB signaling pathway, thus reducing oxidative stress.


Irsogladine maleate (CAS 84504-69-8)

However, serum triglyceride levels were changed, and decreased with the iraogladine of 5 and 50 ppm irsogladine maleate to These results are in line with observations obtained in other colorectal tumor recurrence trials in Western countries using aspirin [ 6 ].

Not Intended for Diagnostic or Therapeutic Use.

N Engl J Med. Chemical structures of six gastric mucosal protectants Irsogladine maleate A. Among the six ,aleate, irsogladine maleate clearly inhibited NF-jB and AP-1 transcriptional activity.

Several RCs, including acetaldehyde, acrolein, 2-nonenal and HNE, are reported to cause damage to DNA and proteins, and this damage is associated with disease development, including chronic inflammation and carcinogenesis [ 21 — 23 ].

Among these, NRF2 and p53 possess anti-carcinogenic potential when activated. The irsoglxdine suggested the effects of 5 ppm irsogladine maleate plateaus, and higher doses did not efficiently decrease polyp numbers. Cardiovascular Research Product Guide. Aspirin for the chemoprevention of colorectal adenomas: Estimates of worldwide burden of cancer in Sign-up for new product e-alerts.

The suppression of intestinal polyp formation in Min mice by irsogladinne maleate The administration of 5 and 50 ppm irsogladine maleate to Min mice for 8 weeks did not affect body weight, food intake or clinical signs throughout the experimental period.

The areas of the circles represent the intensities of the peaks of the detected RCs relative to that of the IS.